The phone comes with a 120 Hz refresh rate 6.5-inch touchscreen display offering a resolution of 1080x2400 pixels and an aspect ratio of 20:9. The display sports Gorilla Glass for protection. Samsung Galaxy A53 5G is powered by an octa-core processor. It comes with 8GB of RAM. The Samsung Galaxy A53 5G runs Android 12 and is powered by a 5000mAh battery. The Samsung Galaxy A53 5G supports proprietary fast charging.

As far as the cameras are concerned, the Samsung Galaxy A53 5G on the rear packs a quad camera setup featuring a 64-megapixel primary camera; a 12-megapixel camera; a 5-megapixel camera, and a 5-megapixel camera. The rear camera setup has autofocus. It has a single front camera setup for selfies, featuring a 32-megapixel sensor with an aperture.

The Samsung Galaxy A53 5G runs One UI 4.1 is based on Android 12 and packs 256GB of inbuilt storage that can be expanded via microSD card (up to 1000GB). The Samsung Galaxy A53 5G is a dual-SIM (GSM and GSM) mobile that accepts Nano-SIM and Nano-SIM cards. It features an IP67 rating for dust and water protection.

Connectivity options on the Samsung Galaxy A53 5G include Wi-Fi 802.11 a/b/g/n/ac, GPS, Bluetooth v5.1, NFC, USB Type-C, 3G, 4G (with support for Band 40 used by some LTE networks in India), and active 5G. Sensors on the phone include accelerometer, ambient light sensor, compass/ magnetometer, gyroscope, proximity sensor, and in-display fingerprint sensor.